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Impact of Actuator Design on Multi-Dose Nasal Spray Characteristics

Authors: Heli Chauhan, Shau Neen Liu-Cordero, Lingzhi Liao, and Joseph Werbeck
Proveris Scientific Corporation

Developing a successful multi-dose nasal spray can be a difficult process. A number of components and critical parameters need to be precisely controlled to achieve desired dose delivery. Numerous studies have focused on the effects of formulation aspects (viscosity, surface tension) on the drug performance. However, device components, including the nozzle/actuators, pump assembly, and dip tube also play a significant role. This study focuses on differences between specific components within the nasal spray device. The pump is responsible for metered delivery of the dose and thereby determines the shot weight of the product. The spray characteristics (spray pattern, plume geometry, and Droplet Size Distribution) of the nasal spray are influenced by formulation, as well as the device, especially the actuator (consisting of the nozzle orifice and swirl chamber). This study focuses on the effect of different actuators by keeping the pump consistent across water and a drug formulation. Understanding the effects of actuator design and formulation on spray pattern can have a significant impact on successful product development.

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