Poster presented at AAPS Annual Meeting and Exposition 2015.

Shaw, C., Smith, M., Richiuso A., Kulkarni V. – DPT Laboratories Ltd., Newcomb A.  – Proveris Scientific Corp.

INTRODUCTION: The formulation properties (viscosity, surface tension and density) and automated actuation parameters (velocity, stroke length, force and acceleration) affect the spray characteristics of unit dose nasal spray devices. During method development, various actuation mode techniques are used to determine actuation parameters. In this study, three actuation modes were compared by assessing the spray characteristics of various formulations to establish the optimal method for actuating unit dose devices.