A comparison of spray characteristics of P-134A and low GWP P-152A pMDIs with and without ethanol

Lynn Jordan1, Sheryl Johnson2, Ramesh Chand1, Grant Thurston1, Deborah Jones1, Vanessa Webster2, Sally Stanford2

1Proveris Scientific Corporation, Hudson, Massachusetts, USA
2Koura, Thornton Science Park, Cheshire, UK

BACKGROUND: As a result of increasing focus on the potential environmental impact associated with pressurized metered dose inhalers (pMDIs) propellants, it is important to understand the options available as well as their possible impact on delivery performance.1 1,1-difluoroethane (P152a) is being explored as one such option as an alternative low Global Warming 

Potential (GWP), non-Per- and Polyfluoroalkyl Substance (PFAS) pMDI propellant. One challenge for the pMDI sector, when developing new formulations based on any new low GWP propellant, is ensuring it can provide adequate or equivalent performance to existing inhalers. Making a change from one pMDI propellant to another is not without challenges and this investigation sets out to study initially the potential impact of a switch from P134a to P152a on spray characteristics using propellant-only cans.

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