Transitioning to low-GWP propellants?Control the variables that matter.
Low-GWP pMDI reformulation can change how a product behaves during shaking, actuation, dose collection, aerosol generation, and through-life use.
As respiratory developers move toward lower-GWP propellants, the development question becomes clear: will the reformulated pMDI still deliver reliable, reproducible, patient-relevant performance across its life? Proveris helps you answer that question with OINDP-focused laboratory services, automated actuation, controlled shaking and fire-down, DDU/APSD collection, SprayVIEW characterization, custom device holders and human-relevant testing strategies.
Low-GWP pMDI evidence pathway
A connected sequence of controlled methods — from formulation sensitivity through visualized spray characterization.
Will the reformulated pMDI still deliver reliable, reproducible, patient-relevant performance across its life?
As propellant systems change, so does the level of control required in development. Small variations in handling, timing, collection and test conditions can introduce uncertainty that masks true formulation and device performance.
As formulation sensitivity increases, seemingly routine variables become critical sources of variability if not deliberately controlled.
- Shaking consistency and suspension resuspension behavior
- Shake-to-fire timing and post-shake delay
- Device positioning and holder stability
- Actuation profile, force, timing and coordination with collection
- DDU collection conditions and through-life B/M/E workflows
- APSD collection conditions and cascade impaction setup
- Spray formation, plume geometry and aerosol dynamics
- Human-relevant breathing, use variability and deposition-oriented studies
Each factor can introduce variability if the method is not intentionally designed and consistently executed.
From reformulation uncertainty to a controlled evidence pathway
Proveris brings together the scientific framework, instrumentation, holder support, applications expertise and laboratory services needed to move from reformulation uncertainty to a controlled evidence pathway. Customers can outsource the study, build internal capacity or combine both approaches as the program matures.
What changes when the propellant changes?
Low-GWP propellant systems can shift product behavior in ways that legacy methods may not fully diagnose.
Suspension Behavior
Formulations may become more sensitive to shaking and timing.
Spray Formation
Plume geometry, evaporation, and aerosol dynamics may shift.
Aerosol Dynamics
Evaporation behavior and aerosol dynamics may change.
Collection Control
DDU and APSD collection may require tighter coordination for device shaking, actuation, flow, and timing.
Internal Components
Valve, actuator, canister and holder interactions may need re-characterization.
Through-life Evidence
B/M/E of life and fire-down workflows reveal drift and sensitivity.
Legacy Manual Workflows
These may not sufficiently diagnose variability.
Reproducible DDU and APSD collection for low-GWP pMDI development
Kinaero Cx + DUSA Tubes + Controlled Actuation
During low-GWP reformulation, the collection workflow becomes part of the evidence strategy. Kinaero® Cx supports controlled, repeatable pMDI actuation and collection workflows, while DUSA tubes and filter-based collection support reproducible delivered-dose sampling. Used together, they help reduce method-induced variability during DDU and APSD-related development studies.
How Proveris helps
Design the study
Use Proveris applications expertise and laboratory support to define the right low-GWP pMDI evidence pathway.
Control actuation and shaking
Use Vereo automated actuator technology to reduce variability in shaking, actuation profile, and timing.
Scale through-life workflows
Use Kinaero to support high-throughput, through-life B/M/E fire-down studies.
Collect DDU/APSD samples
Use Kinaero Cx with DUSA tubes and controlled collection workflows to strengthen dose and aerosol evidence.
Characterize spray behavior
Use SprayVIEW and Proveris laboratory services to evaluate plume geometry, spray pattern and visualized performance changes.
Add real-use context
Connect controlled methods with human actuation, breathing simulation, and deposition-oriented studies where appropriate.
Secure the device. Control the method. Trust the data.
Every pMDI geometry creates practical handling questions. During low-GWP development, these questions become more important because formulation, valve, and actuator changes may already be increasing performance sensitivity.
Proveris supports reproducible positioning through device holders designed for specific product geometries. By keeping the pMDI stable during actuation and collection, holders reduce avoidable variability and strengthen the overall control strategy.
Start your low-GWP pMDI strategy
Bring your formulation stage, device questions, method concerns, and current testing bottlenecks. We will help you determine whether to begin with a laboratory study, an instrument workflow, or a combined development plan.
Schedule a Strategy Discussion