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Proveris Scientific presents poster on factors effecting multi-dose nasal spray characteristics at RDD 2018

April 16th, 2018 | Posted in Proveris News

Impact of Actuator Design on Multi Dose Nasal Spray Characteristics.

Authors: Heli Chauhan, Shau Neen Liu-Cordero, Lingzhi Liao, and Joseph Werbeck
Proveris Scientific Corporation

Developing a successful multi-dose nasal spray can be a difficult process. A number of components and critical parameters need to be precisely controlled to achieve desired dose delivery. Numerous studies have focused on the effects of formulation aspects (viscosity, surface tension) on the drug performance. However, device components, including the nozzle/actuators, pump assembly, and dip tube also play a significant role. This study focuses on differences between specific components within the nasal spray device. The pump is responsible for metered delivery of the dose and thereby determines the shot weight of the product. The spray characteristics (spray pattern, plume geometry, and Droplet Size Distribution) of the nasal spray are influenced by formulation, as well as the device, especially the actuator (consisting of the nozzle orifice and swirl chamber). This study focuses on the effect of different actuators by keeping the pump consistent across water and a drug formulation. Understanding the effects of actuator design and formulation on spray pattern can have a significant impact on successful product development.

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"Proveris Scientific Corporation provides expert support for nasal developers. They are fast, reliable and are professionals at installing of their equipment and supports in demanding challenges." Dr. Peter Svete, Head of Physical Analytics, Lek Pharmaceuticals d.d.
 
 
"Proveris provides insightful and thorough test services. We would recommend working with Proveris. Proveris has great expertise in spray analysis." Elaine Schutte, Chief Development Officer, ProFibrix
 
 
"I want to express my sincere gratitude towards Proveris and the service team for being there to make sure our study goes well. The study just completed few minutes ago and thankfully everything went well.......while we conducted SAC study. It was a great display of professionalism by Proveris." ,
 
 
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