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Publication entries for Doub WH

William H. Doub1, Vibhaker Shah2, Susan Limb3, Changning Guo1, Xiaofei Liu1, Diem Ngo1 1US FDA/OMPT/CDER/OPS/OTR/ Division of Pharmaceutical Analysis, Saint Louis, MO 2US FDA/OMPT/CDER/OC/OMPQ/DGMPA/NDMAB, Silver Spring, MD 3US FDA/OMPT/CDER/OND/ODEII/Division of Pulmonary, Allergy, and Rheumatology Products, Silver Spring, MD Received 20 December 2013; revised 18 July 2014; accepted 7 August 2014 Published online in Wiley Online […]

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Pharm Res. 2012 Nov;29(11):3122-30. doi: 10.1007/s11095-012-0804-7. Epub 2012 Jul 3. Doub WH1, Adams WP, Wokovich AM, Black JC, Shen M, Buhse LF. Corresponding author:  william.doub@fda.hhs.gov 1Division of Pharmaceutical Analysis, Food and Drug Administration CDER, OPS, St. Louis, Missouri, USA. ABSTRACT PURPOSE: To determine if cascade impactor (CI) measurement of drug in small particles from aqueous nasal sprays, described in FDA’s 2003 draft Nasal […]

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Journal of Pharmaceutical Sciences, 99(4):2114-2122 (April 2010). Guo C1, Doub WH, Kauffman JF. Corresponding author: changning.guo@fda.hhs.gov 1Division of Pharmaceutical Analysis, U.S. Food and Drug Administration, 1114 Market Street, Room 1002, St. Louis, Missouri 63101 Abstract Design of experiment (DOE) methodology can provide a complete evaluation of the influences of nasal spray activation and formulation properties on delivery performance […]

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Int J Pharm. 2010 Mar 30;388(1-2):82-7. doi: 10.1016/j.ijpharm.2009.12.041. Epub 2010 Jan 5. Liu X1, Doub WH, Guo C. U.S. Food & Drug Administration, Division of Pharmaceutical Analysis, 1114 Market Street, Room 1002, St. Louis, MO 63101, United States   Abstract To determine aerosol deposition during the inhalation drug delivery, it is important to understand the combination of velocity […]

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Journal of Pharmaceutical Sciences, 98(8):2799-2806 (August 2009). Guo C, Ye W, Kauffman JF, Doub WH. Corresponding author: changning.guo@fda.hhs.gov U.S. Food & Drug Administration, Division of Pharmaceutical Analysis, 1114 Market Street, Room 1002, St. Louis, Missouri 63101 Abstract The impaction force from an inhalation product is an important characteristics by which to characterize the spray plume. It is one of […]

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European Journal of Pharmaceutical Sciences, 35(5):418-426 (September 2008). Guo Ca, Stine KJb, Kauffman JFa, Doub WHa. Corresponding author: changning.guo@fda.hhs.gov aDivision of Pharmaceutical Analysis, U.S. Food and Drug Administration, 1114 Market Street, Room 1002, St. Louis, MO 63101, United States bDepartment of Chemistry and Biochemistry and Center for Nanoscience, University of Missouri at St. Louis, 315 Benton Hall, One University […]

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Journal of Pharmaceutical Sciences, 97(8):3321-3334 (August 2008). Guo C, Gillespie SR, Kauffman J, Doub WH. Corresponding author: changning.guo@fda.hhs.gov U.S. Food and Drug Administration, Division of Pharmaceutical Analysis, 1114 Market Street, Room 1002, St. Louis, Missouri 63101 Abstract The purpose of this research was to compare two cascade impaction devices for the aerodynamic particle size assessment of a combination metered-dose […]

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Journal of Pharmaceutical Sciences, 95(9):2029-2040 (September 2006). Guo C, Doub WH. Corresponding author: changning.guo@fda.hhs.gov Division of Pharmaceutical Analysis, U. S. Food and Drug Administration, 1114 Market Street, Room 1002, St. Louis, Missouri 63101 Abstract Nasal spray drug products are normally characterized via measurement of shot weight, spray pattern, plume geometry, and droplet size distribution (DSD). In this […]

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